Clotting factors and eicosanoids protect against nematode infections
Autoři | |
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Rok publikování | 2011 |
Druh | Článek v odborném periodiku |
Časopis / Zdroj | Journal of Innate Immunity |
Fakulta / Pracoviště MU | |
Citace | |
Obor | Imunologie |
Klíčová slova | Drosophila melanogaster; eicosanoids; entomopathogenic nematodes; Heterorhabditis bacteriophora; transglutaminase; coagulation; Photorhabdus luminescens |
Popis | We show that hemolymph clotting protects Drosophila melanogaster against infections with an entomopathogenic nematode and its symbiotic bacterium. We also provide biochemical and genetic evidence for an involvement of eicosanoids in the same infection model. Taken together our results confirm the conserved nature of the immune function of clot formation. |
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