Clotting factors and eicosanoids protect against nematode infections

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Authors

HYRŠL Pavel DOBEŠ Pavel WANG Zhi HAULING Thomas WILHELMSSON Christine THEOPOLD Ulrich

Year of publication 2011
Type Article in Periodical
Magazine / Source Journal of Innate Immunity
MU Faculty or unit

Faculty of Science

Citation
Field Immunology
Keywords Drosophila melanogaster; eicosanoids; entomopathogenic nematodes; Heterorhabditis bacteriophora; transglutaminase; coagulation; Photorhabdus luminescens
Description We show that hemolymph clotting protects Drosophila melanogaster against infections with an entomopathogenic nematode and its symbiotic bacterium. We also provide biochemical and genetic evidence for an involvement of eicosanoids in the same infection model. Taken together our results confirm the conserved nature of the immune function of clot formation.
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