DNA repair mechanisms in yeast

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Publikace nespadá pod Ekonomicko-správní fakultu, ale pod Lékařskou fakultu. Oficiální stránka publikace je na webu muni.cz.
Název česky DNA opravné mechanismy u kvasinek
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KREJČÍ Lumír

Rok publikování 2009
Druh Článek ve sborníku
Konference 37th Annual Conference on Yeast
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www http://www.chem.sk/yeast/konferencia/conf37.html
Obor Biochemie
Klíčová slova DNA repair; DNA damage; replication; genomic instability
Popis DNA replication is typically highly processive mechanism with astonishing precision, despite the fact that it frequently encounters barriers caused by endogenous and exogenous genotoxic agents. It is not surprising that DNA replication does not act alone, but operates in coordination with homologous recombination (HR), and other DNA repair processes to overcome such replication obstacles to ensure cellular viability, and achieve genomic stability. Numerous mechanisms by which replication forks can be restarted following arrest have been described. Some of the pathways enable the cells to deal with such impediments while keeping the fork in place, including repriming, template switch, and translesion synthesis, others may provoke partial or complete fork collapse followed by fork reversal. This could not only provide time and space for repair but also liberate the new strand to undergo template switch. Alternatively, the fork can be cleaved, creating the DSB break that is repaired by recombination machinery with ability to restart the replication fork. Inability to remove toxic DNA structures often leads to their accumulation, higher mutation frequency and eventually to cancer or other diseases associated with genomic instability.
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