C-13 Relaxation Studies of RNA Dynamics: Challenges and Solutions
Název česky | Studium dynamiky RNA pomocí relaxace C-13: Problémy a jejich řešení |
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Autoři | |
Rok publikování | 2008 |
Druh | Článek ve sborníku |
Konference | XXIII International Conference on Magnetic Resonance in Biological Systems |
Fakulta / Pracoviště MU | |
Citace | |
Obor | Biofyzika |
Klíčová slova | NMR; nucleic acids;RNA;dynamics |
Popis | NMR relaxation experiments provide a way of monitoring molecular dynamics with atomic resolution. However, the measurement of 13C relaxation rates and their interpretation faces serious challenges. We have modified the Model-Free procedure to explicitly take into account asymmetric character of the carbon chemical shielding tensors and the effect of neighboring nuclei. The extended version of the Model-Free analysis generally produces more realistic values of the order parameter. |
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