Common xanthene fluorescent dyes are visible-light activatable CO-releasing molecules

• Autoři: MARTÍNEK Marek; LUDVÍKOVÁ Lucie; ŠRANKOVÁ Mária; NAVRÁTIL Rafael; MUCHOVÁ Lucie; HUZLÍK Jiří; VÍTEK Libor; KLÁN Petr; ŠEBEJ Peter
• Rok publikování: 2023
• Druh: Článek v odborném periodiku
• Časopis / Zdroj: Organic and Biomolecular Chemistry
• Fakulta / Pracoviště MU: Přírodovědecká fakulta
• www: https://pubs.rsc.org/en/content/articlelanding/2023/OB/D2OB01823C
• Doi: http://dx.doi.org/10.1039/d2ob01823c
• Klíčová slova: CARBON-MONOXIDE; QUANTUM YIELD; EOSIN-Y; PHOTOCHEMISTRY; OXYGEN; PHOTODEGRADATION; ANGIOGRAPHY; MECHANISM
• Popis: Fluorescein, eosin Y, and rose bengal are dyes used in clinical medicine and considered (photo-)chemically stable. Upon extensive irradiation with visible light in aqueous solutions, we found that these compounds release carbon monoxide (CO) - a bioactive gasotransmitter - in 40-100% yields along with the production of low-mass secondary photoproducts, such as phthalic and formic acids, in a multistep degradation process. Such photochemistry should be considered in applications of these dyes, and they could also be utilized as visible-light activatable CO-releasing molecules (photoCORMs) with biological implications.

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