Common xanthene fluorescent dyes are visible-light activatable CO-releasing molecules

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Authors	MARTÍNEK Marek LUDVÍKOVÁ Lucie ŠRANKOVÁ Mária NAVRÁTIL Rafael MUCHOVÁ Lucie HUZLÍK Jiří VÍTEK Libor KLÁN Petr ŠEBEJ Peter
Year of publication	2023
Type	Article in Periodical
Magazine / Source	Organic and Biomolecular Chemistry
MU Faculty or unit	Faculty of Science
Citation
Web	https://pubs.rsc.org/en/content/articlelanding/2023/OB/D2OB01823C
Doi	http://dx.doi.org/10.1039/d2ob01823c
Keywords	CARBON-MONOXIDE; QUANTUM YIELD; EOSIN-Y; PHOTOCHEMISTRY; OXYGEN; PHOTODEGRADATION; ANGIOGRAPHY; MECHANISM
Description	Fluorescein, eosin Y, and rose bengal are dyes used in clinical medicine and considered (photo-)chemically stable. Upon extensive irradiation with visible light in aqueous solutions, we found that these compounds release carbon monoxide (CO) - a bioactive gasotransmitter - in 40-100% yields along with the production of low-mass secondary photoproducts, such as phthalic and formic acids, in a multistep degradation process. Such photochemistry should be considered in applications of these dyes, and they could also be utilized as visible-light activatable CO-releasing molecules (photoCORMs) with biological implications.
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