Prolonged survival in patients with local chronic infection after high-grade glioma treatment: two case reports

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Publikace nespadá pod Ekonomicko-správní fakultu, ale pod Lékařskou fakultu. Oficiální stránka publikace je na webu muni.cz.
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SOLÁR Peter MACKERLE Zdeněk HENDRYCH Michal POSPÍŠIL Petr LAKOMÝ Radek VALEKOVÁ Hana HERMANOVÁ Markéta JANČÁLEK Radim

Rok publikování 2022
Druh Článek v odborném periodiku
Časopis / Zdroj FRONTIERS IN ONCOLOGY
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www https://www.frontiersin.org/articles/10.3389/fonc.2022.1073036/full
Doi http://dx.doi.org/10.3389/fonc.2022.1073036
Klíčová slova high-grade glioma; glioblastoma; anaplastic astrocytoma; wound infection; prolonged survival
Popis High-grade gliomas are primary brain tumors with poor prognosis, despite surgical treatment followed by radiotherapy and concomitant chemotherapy. We present two cases of long-term survival in patients treated for high-grade glioma and concomitant prolonged bacterial wound infection. The first patient treated for glioblastoma IDH-wildtype had been without disease progression for 61 months from the first resected recurrence. Despite incomplete chemotherapy-induced myelosuppression in the second patient with anaplastic astrocytoma IDH-mutant, she died without disease relapse after 14 years from the diagnosis due to other comorbidities. We assume that the documented prolonged survival could be related to the bacterial infection.
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