Prolonged survival in patients with local chronic infection after high-grade glioma treatment: two case reports

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Authors

SOLÁR Peter MACKERLE Zdeněk HENDRYCH Michal POSPÍŠIL Petr LAKOMÝ Radek VALEKOVÁ Hana HERMANOVÁ Markéta JANČÁLEK Radim

Year of publication 2022
Type Article in Periodical
Magazine / Source FRONTIERS IN ONCOLOGY
MU Faculty or unit

Faculty of Medicine

Citation
Web https://www.frontiersin.org/articles/10.3389/fonc.2022.1073036/full
Doi http://dx.doi.org/10.3389/fonc.2022.1073036
Keywords high-grade glioma; glioblastoma; anaplastic astrocytoma; wound infection; prolonged survival
Description High-grade gliomas are primary brain tumors with poor prognosis, despite surgical treatment followed by radiotherapy and concomitant chemotherapy. We present two cases of long-term survival in patients treated for high-grade glioma and concomitant prolonged bacterial wound infection. The first patient treated for glioblastoma IDH-wildtype had been without disease progression for 61 months from the first resected recurrence. Despite incomplete chemotherapy-induced myelosuppression in the second patient with anaplastic astrocytoma IDH-mutant, she died without disease relapse after 14 years from the diagnosis due to other comorbidities. We assume that the documented prolonged survival could be related to the bacterial infection.
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