Molecular Dynamics Simulations of RNA Molecules

Varování

Publikace nespadá pod Ekonomicko-správní fakultu, ale pod Středoevropský technologický institut. Oficiální stránka publikace je na webu muni.cz.

Autoři	ŠPONER Jiří OTYEPKA Michal BANÁŠ Pavel RÉBLOVÁ Kamila WALTER Nils
Rok publikování	2012
Druh	Kapitola v knize
Fakulta / Pracoviště MU	Středoevropský technologický institut
Citace
Popis	The central role of RNA in numerous biological processes including translation, protein localization, gene regulation, RNA processing, and viral replication calls for a detailed understanding of RNA function, structure, and conformational dynamics. Accompanying and enhancing our increasing appreciation of RNA is the rapidly expanding availability of high-resolution structures of RNAs and RNA-protein (RNP) complexes. These atomic resolution snapshots provide detailed rationalization for existing biochemical data. However, biological function depends on the dynamic evolution of structures along functional pathways. A complete understanding of the relevant structural dynamics exhibited by RNA requires monitoring timescales from picoseconds to hours through the application of a correspondingly broad range of techniques, with careful consideration given to the scope and limitation of each approach.
Související projekty:	Biomolekulární centrum