Molecular Dynamics Simulations of RNA Molecules

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Authors

ŠPONER Jiří OTYEPKA Michal BANÁŠ Pavel RÉBLOVÁ Kamila WALTER Nils

Year of publication 2012
Type Chapter of a book
MU Faculty or unit

Central European Institute of Technology

Citation
Description The central role of RNA in numerous biological processes including translation, protein localization, gene regulation, RNA processing, and viral replication calls for a detailed understanding of RNA function, structure, and conformational dynamics. Accompanying and enhancing our increasing appreciation of RNA is the rapidly expanding availability of high-resolution structures of RNAs and RNA-protein (RNP) complexes. These atomic resolution snapshots provide detailed rationalization for existing biochemical data. However, biological function depends on the dynamic evolution of structures along functional pathways. A complete understanding of the relevant structural dynamics exhibited by RNA requires monitoring timescales from picoseconds to hours through the application of a correspondingly broad range of techniques, with careful consideration given to the scope and limitation of each approach.
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