Mutual cytokine crosstalk between colon cancer cells and microenvironment initiates development of distant metastases

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Publikace nespadá pod Ekonomicko-správní fakultu, ale pod Lékařskou fakultu. Oficiální stránka publikace je na webu muni.cz.
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VAŇHARA Petr SOUČEK Karel

Rok publikování 2013
Druh Článek v odborném periodiku
Časopis / Zdroj JAK-STAT
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www https://www.landesbioscience.com/journals/jak-stat/2012JAKS0099.pdf
Doi http://dx.doi.org/10.4161/jkst.23810
Obor Genetika a molekulární biologie
Klíčová slova metastasis; transforming growth factor-b; interleukin 11; metastatic niche; tumor stroma; dissemination; microenvironment
Popis Tumor growth and cancer development are considered clear examples of Darwinian selection, whereby random mutational events in heterogeneous cancer cell populations that best fit the selective microenvironment are preferred.1 As a result, cancer cells evolve resistance to apoptosis, hide from immune surveillance and acquire the ability to invade other organs. Cancer cells, however, are not necessarily passive subjects of selection; they can actively subvert the host tissue to provide a favorable habitat for their growth. Recent findings by Calon et al. convincingly demonstrate that transforming growth factor-b-induced secretion of interleukin 11 by tumor stromal fibroblasts is a necessary prerequisite for the development of distant metastases in colorectal carcinoma. Thus, understanding the complex molecular feedback loops between cancer cells and the surrounding microenvironment (i.e., the tumor-associated stroma or invaded host tissue) should aid the identification of useful molecular targets for improving clinical management of advanced metastatic cancers.
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