Informace o projektu
Czech Infrastructure for Integrative Structural Biology
(CIISB)
- Kód projektu
- LM2015043
- Období řešení
- 1/2016 - 12/2019
- Investor / Programový rámec / typ projektu
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Ministerstvo školství, mládeže a tělovýchovy ČR
- Velké infrastruktury pro výzkum, vývoj a inovace
- Fakulta / Pracoviště MU
-
Středoevropský technologický institut
- prof. RNDr. Vladimír Sklenář, DrSc.
The Czech Infrastructure for Integrative Structural Biology (CIISB) is a distributed infrastructure of the core facilities and central laboratories of CEITEC (Central European Institute of Technology, Brno) and BIOCEV (Biotechnology and Biomedicine Centre, Vestec, Prague-West) providing expertise and access to technologies used for integrative approaches to structural analysis of biologically important cellular components and macromolecules - proteins, nucleic acids, and their complexes. CIISB, equipped with the cutting-edge technologies (total investments will exceed 750 mil. CZK by the end of 2015), will offer access to the equipment and expertise in the following fields: high-field NMR spectroscopy; high throughput crystallization of biological macromolecules; X-ray diffraction techniques; Bio-SAXS measurements; AFM imaging; characterization of proteins, nucleic acids and complexes by biophysical methods including microcalorimetry, dynamic light scattering, and surface plasmon resonance; high-end cryo-electron microscopy and tomography allowing studies of cellular structures, organelles, and biomacromolecular complexes by 3D imaging; protein expression in eukaryotic cells; high-end mass spectrometry characterization of biomacromolecules; determination of protein post-translational modifications; MS-based peptide mapping/sequencing; high throughput sequencing and proteomic services. CIISB infrastructure aims to provide a high quality open access services in provision of methods and techniques on a level of national and trans-national importance. CIISB as National Affiliated Center is a part of the ESFRI projects INSTRUCT.
Publikace
Počet publikací: 239
2018
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Virion structure and genome delivery mechanism of sacbrood honeybee virus
Proceedings of the National Academy of Sciences of the United States of America, rok: 2018, ročník: 115, vydání: 30, DOI
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Visualization of translation termination intermediates trapped by the Apidaecin 137 peptide during RF3-mediated recycling of RF1
Nature Communications, rok: 2018, ročník: 9, vydání: AUG, DOI
2017
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2nd single crystal diffraction workshop
Rok: 2017, druh: Uspořádání workshopu
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A Concise Synthesis of Forskolin
Angewandte Chemie International Edition, rok: 2017, ročník: 2017, vydání: 56, DOI
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A New Cucurbituril Derivative that Exhibits Cation-Modulated Self-Assembly
Rok: 2017, druh: Další prezentace na konferencích
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A New Two-Step Chromatographic Procedure for Fractionation of Potato Proteins with Potato Fruit Juice and Spray-Dried Protein as Source Materials
Food and Bioprocess Technology, rok: 2017, ročník: 10, vydání: 11, DOI
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A novel type I cystatin of parasite origin with atypical legumain-binding domain
Scientific Reports, rok: 2017, ročník: 7, vydání: December, DOI
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A proteomic analysis of LRRK2 binding partners reveals interactions with multiple signaling components of the WNT/PCP pathway
MOLECULAR NEURODEGENERATION, rok: 2017, ročník: 12, vydání: 54, DOI
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Acinetobacter colistiniresistens sp nov (formerly genomic species 13 sensu Bouvet and Jeanjean and genomic species 14 sensu Tjernberg and Ursing), isolated from human infections and characterized by intrinsic resistance to polymyxins
International Journal of Systematic and Evolutionary Microbiology, rok: 2017, ročník: 67, vydání: 7, DOI
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AgNi core-shell nanoparticles by hot injection synthesis
Rok: 2017, druh: Konferenční abstrakty