Project information
Molecular basis of cell and tissue regulations
- Project Identification
- MSM0021622415
- Project Period
- 1/2005 - 12/2011
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Central European Institute of Technology
- Other MU Faculty/Unit
- Faculty of Medicine
- Keywords
- Cell; genomics; proteomics; biomedicine; gene expression; regulation mechanisms; chromatin structure; structure and interactions of biomolecules
The cell is a system in which each molecule is a component of interaction network. Due to the highly complex interconnection, function of cells and organisms is relatively resistant to failure of individual components of the network. Convergence of thought and methodical approaches which is characteristic for today’s postgenomic era, is a basis for interconnection of research capacities of molecular-biology oriented workgroups of the Masaryk University in the proposed Research Plan (RP). Solving of the RP will proceed in 4 program areas: 1. Regulation mechanisms in animal cells; 2. Functional domains of eukaryotic chromosomes; 3. Genomics and proteomics of regulation circuits in plants; 4. Functional analysis of the genome of clinically and biotechnologically important bacteria. The RP objective is to use approaches of structural biology, functional genomics, proteomics and bioinformatics to elucidate molecular basis of processes which are important from the viewpoint of perspective biomedical and biotechnology applications.
Publications
Total number of publications: 1205
2013
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The occurrence of Borrelia burgdorferi sensu lato in certain ectoparasites (Mesostigmata, Siphonaptera) of Apodemus flavicollis and Myodes glareolus in chosen localities in the Czech Republic
Acta Parasitologica, year: 2013, volume: 58, edition: 3, DOI
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Towards functional repertoire of the earliest proteins
Journal of Biomolecular Structure & Dynamics, year: 2013, volume: 31, edition: 11, DOI
2012
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Analysis of GFP and AHP5-GFP Fusion Protein in the Plant Extract Using CE-LIF
CECE 2012 9th International Interdisciplinary Meeting on Bioanalysis, year: 2012
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Analysis of chromosomal abnormalities in phenotypically normal plasma cells detected by I-FISH in monoclonal gammopathy of undetermined significance
Year: 2012, type: Conference abstract
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Analysis of the Nse3/MAGE-binding Domain of the Nse4/EID Family Proteins
PLoS One, year: 2012, volume: 7, edition: 4, DOI
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Apoptotic cleavage of DNA in human lymphocyte chromatin shows high sequence specificity
J. Biomol. Struct. Dynamics, year: 2012, volume: 30, edition: 2, DOI
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Application of immobilized RNases in molecular biology and biotechnology
Advances in Medicine and Biology, edition: Vyd. 1, year: 2012, number of pages: 14 s.
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Author Response Definition of Life: Navigation through Uncertainties
J. Biomol. Struct. Dynamics, year: 2012, volume: 29, edition: 4
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Beer fingerprinting by Matrix-Assisted Laser Desorption-Ionisation-Time of Flight Mass Spectrometry
Food Chemistry, year: 2012, volume: 135, edition: 2, DOI
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Borelie v klíšťatech v Brně a prevence nemocí přenášených klíšťaty
Year: 2012, type: Conference abstract