Apoptotic cleavage of DNA in human lymphocyte chromatin shows high sequence specificity

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Authors	BETTECKEN Thomas FRENKEL Zakharia M ALTMUELLER Janine NUERNBERG Peter TRIFONOV Eduard Nikolajevič
Year of publication	2012
Type	Article in Periodical
Magazine / Source	J. Biomol. Struct. Dynamics
MU Faculty or unit	Central European Institute of Technology
Citation
Web	http://www.tandfonline.com/doi/abs/10.1080/07391102.2012.677772
Doi	http://dx.doi.org/10.1080/07391102.2012.677772
Field	Genetics and molecular biology
Keywords	apoptosis; DNA fragmentation; apoptotic ladder; nucleosome
Description	Apoptotic digestion of human lymphocyte chromatin results in the appearance of large amounts of nucleosome size DNA fragments.his consensus also possesses three TA dinucleotide steps, separated by five bases (corresponding to a half-period of the DNA double helix), suggesting strong bending of the DNA at the cut sites which is perhaps required for cutting.
Related projects:	Molecular basis of cell and tissue regulations CHROMPLANT