Project information
Molecular basis of cell and tissue regulations
- Project Identification
- MSM0021622415
- Project Period
- 1/2005 - 12/2011
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Central European Institute of Technology
- Other MU Faculty/Unit
- Faculty of Medicine
- Keywords
- Cell; genomics; proteomics; biomedicine; gene expression; regulation mechanisms; chromatin structure; structure and interactions of biomolecules
The cell is a system in which each molecule is a component of interaction network. Due to the highly complex interconnection, function of cells and organisms is relatively resistant to failure of individual components of the network. Convergence of thought and methodical approaches which is characteristic for today’s postgenomic era, is a basis for interconnection of research capacities of molecular-biology oriented workgroups of the Masaryk University in the proposed Research Plan (RP). Solving of the RP will proceed in 4 program areas: 1. Regulation mechanisms in animal cells; 2. Functional domains of eukaryotic chromosomes; 3. Genomics and proteomics of regulation circuits in plants; 4. Functional analysis of the genome of clinically and biotechnologically important bacteria. The RP objective is to use approaches of structural biology, functional genomics, proteomics and bioinformatics to elucidate molecular basis of processes which are important from the viewpoint of perspective biomedical and biotechnology applications.
Publications
Total number of publications: 1209
2005
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Stanovení aktivity telomerázy u mnohočetného myelomu
Klinická onkologie, year: 2005, volume: 18, edition: 3
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<I>Staphylococcus simiae </I>sp. nov., isolated from South American squirrel monkeys
International Journal of Systematic and Evolutionary Microbiology, year: 2005, volume: 55, edition: 5
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<I>Staphylococcus simiae</I> sp. nov.
Správy klinickej mikrobiológie, year: 2005, volume: 5, edition: Suppl. B.
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Structural Variability of Subtelomeres Applied for Genotyping of Selected Potato Varieties
Czech J. Genet. Plant Breed., year: 2005, volume: 41, edition: 1
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Studium domnělých regulátorů genové exprese a sigma 54-závislých promotorů spirochety Treponema pallidum.
Year: 2005, type: Conference abstract
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Studium domnělých regulátorů genové exprese spirochety Treponema pallidum.
Year: 2005, type: Conference abstract
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Studium genové exprese u T. pallidum.
Sborník příspěvků IX. Pracovního setkání biochemiků a molekulárních biologů, year: 2005
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Study of Derivatization of Peptides and Proteins for Fluorescence Detection Using Capillary Electrophoresis and Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry
Year: 2005, type: Conference abstract
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Study of Fluorescently Labelled Peptides and Small Proteins Using Capillary Electrophoresis Combined with Laser Induced Fluorescence and MALDI MS Detection
Collection Symposium Series, Biollogicaly Active Peptides, year: 2005
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Techniques in plant telomere biology
BioTechniques, year: 2005, volume: 38, edition: 2