Project information
Molecular basis of cell and tissue regulations
- Project Identification
- MSM0021622415
- Project Period
- 1/2005 - 12/2011
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Central European Institute of Technology
- Other MU Faculty/Unit
- Faculty of Medicine
- Keywords
- Cell; genomics; proteomics; biomedicine; gene expression; regulation mechanisms; chromatin structure; structure and interactions of biomolecules
The cell is a system in which each molecule is a component of interaction network. Due to the highly complex interconnection, function of cells and organisms is relatively resistant to failure of individual components of the network. Convergence of thought and methodical approaches which is characteristic for today’s postgenomic era, is a basis for interconnection of research capacities of molecular-biology oriented workgroups of the Masaryk University in the proposed Research Plan (RP). Solving of the RP will proceed in 4 program areas: 1. Regulation mechanisms in animal cells; 2. Functional domains of eukaryotic chromosomes; 3. Genomics and proteomics of regulation circuits in plants; 4. Functional analysis of the genome of clinically and biotechnologically important bacteria. The RP objective is to use approaches of structural biology, functional genomics, proteomics and bioinformatics to elucidate molecular basis of processes which are important from the viewpoint of perspective biomedical and biotechnology applications.
Publications
Total number of publications: 1209
2005
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Identifikace modifikátorových genů pozdního kvetení u Arabidopsis thaliana
IX. Pracovní setkání biochemiků a molekulárních biologů, year: 2005
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Identifikace neznámých spirochét v DFM pozitivních vzorcích
Year: 2005, type: Conference abstract
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Identifikace regulátorů genové exprese u Treponema pallidum.
Sborník příspěvků IX. Pracovního setkání biochemiků a molekulárních biologů, year: 2005
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Imunomagnetická separace buněk z kostní dřeně u pacientů s mnohočetným myelomem stanovení delece 13q14 použitím interfázní fluorescenční in situ hybridizace
Klinická onkologie, year: 2005, volume: 18, edition: 2
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In vitro testing of vancomycin - gentamicin loaded bone cement to prevent prosthetic joint infection
Biomedical Papers, year: 2005, volume: 149, edition: 1
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Indirect quantification of protein modification degree
Year: 2005, type: Conference abstract
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Interaction of fibroblast growth factor and C-natriuretic peptide signaling inregulation of chondrocyte proliferation and extracellular matrix homeostasis.
Journal of Cell Science, year: 2005, volume: 118, edition: 21, DOI
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Ionizace MALDI a její využití ve spojení se separačními technikami
Year: 2005, type: R&D Presentation
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Isolation and characterization of a novel semi-lethal Arabidopsis thaliana mutant of gene for pentatricopeptide (PPR) repeat-containing protein
Book of Abstracts, 6th International Symposium in the Series Recent Advances in Plant Biotechnology, 12.-16.9.2005, year: 2005
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Jak vznikají nádory?
Universitas, year: 2005, volume: 38, edition: 4