MicroRNAs in Solid Cancer: From Biomarkers to Therapeutic Targets
| Autoři | |
|---|---|
| Rok publikování | 2012 |
| Druh | Odborná kniha |
| Fakulta / Pracoviště MU | |
| Citace | |
| Popis | MiRNA is extremely fast growing field, and miRNA knowledge is now believed to be a pivotal element of cancer biology. An individual miRNA interferes with a broad range of mRNAs; conversely, a single mRNA could be targeted by a variety of miRNAs. The complexity of miRNA:mRNA interaction is far-reaching and a bit beyond our understanding to date. It is already evident that the discovery of miRNA has created a paradigm shift in post-genomics biology, not only for scientists accustomed to traditional central dogma of molecular biology but also for researchers studying human diseases and accustomed to traditional genetics approach of studying one gene at the time. The ability of miRNAs to control large groups of genes and impose global post-transcriptional regulation of many (if not all) important cellular processes in development, cell proliferation and differentiation has opened up a new dimension and uncovered complexity of intracellular regulatory processes. This book is expected to provide introduction to the basic principles of miRNA biology, overview of miRNA significance in the hallmarks of cancer, experimental techniques used in miRNA research, and in special part - miRNAs importance in wide range of solid cancers with a special focus on its potential usage in molecular pathology, predictive oncology or as a novel therapeutic targets. |
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