Unveiling the mystery of déja vu: The structural anatomy of déja vu

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Publikace nespadá pod Ekonomicko-správní fakultu, ale pod Středoevropský technologický institut. Oficiální stránka publikace je na webu muni.cz.
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BRÁZDIL Milan MAREČEK Radek URBÁNEK Tomáš KAŠPÁREK Tomáš MIKL Michal REKTOR Ivan ZEMAN Adam

Rok publikování 2012
Druh Článek v odborném periodiku
Časopis / Zdroj Cortex
Fakulta / Pracoviště MU

Středoevropský technologický institut

Citace
www http://www.cortexjournal.net/article/S0010-9452%2812%2900088-3/abstract
Doi http://dx.doi.org/10.1016/j.cortex.2012.03.004
Obor Neurologie, neurochirurgie, neurovědy
Klíčová slova déja vu; source-based morphometry; temporal lobe epilepsy; neuroanatomy; postnatal neurogenesis
Popis Deéja vu (DV) is a widespread, fascinating and mysterious human experience. It occurs both in health and in disease, notably as an aura of temporal lobe epilepsy. This feeling of inappropriate familiarity has attracted interest from psychologists and neuroscientists for over a century, but still there is no widely agreed explanation for the phenomenon of non-pathological DV. Here we investigated differences in brain morphology between healthy subjects with and without DV using a novel multivariate neuroimaging technique, Source-Based Morphometry. The analysis revealed a set of cortical (predominantly mesiotemporal) and subcortical regions in which there was significantly less gray matter in subjects reporting DV. In these regions gray matter volume was inversely correlated with the frequency of DV. Our results demonstrate a structural correlate of DV in healthy individuals for the first time and support a neurological explanation for the phenomenon. We hypothesis that the observed local gray matter decrease in subjects experiencing DV reflects an alteration of hippocampal function and postnatal neurogenesis with resulting changes of volume in remote brain regions.
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