Novel classes of non-coding RNAs and cancer
| Autoři | |
|---|---|
| Rok publikování | 2012 |
| Druh | Článek v odborném periodiku |
| Časopis / Zdroj | Journal of Translational Medicine |
| Fakulta / Pracoviště MU | |
| Citace | |
| www | http://www.translational-medicine.com/content/pdf/1479-5876-10-103.pdf |
| Doi | http://dx.doi.org/10.1186/1479-5876-10-103 |
| Obor | Onkologie a hematologie |
| Klíčová slova | non-coding RNAs; microRNAs; siRNAs; piRNAs; lncRNAs; cancer |
| Popis | For the many years, the central dogma of molecular biology has been that RNA functions mainly as an informational intermediate between a DNA sequence and its encoded protein. But one of the great surprises of modern biology was the discovery that protein-coding genes represent less than 2% of the total genome sequence, and subsequently the fact that at least 90% of the human genome is actively transcribed.Thus, the human transcriptome was found to be more complex than a collection of protein-coding genes and their splice variants. Although initially argued to be spurious transcriptional noise or accumulated evolutionary debris arising from the early assembly of genes and/or the insertion of mobile genetic elements, recent evidence suggests that the non-coding RNAs (ncRNAs) may play major biological roles in cellular development, physiology and pathologies, including cancer. |
| Související projekty: |