Novel classes of non-coding RNAs and cancer

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Publikace nespadá pod Ekonomicko-správní fakultu, ale pod Středoevropský technologický institut. Oficiální stránka publikace je na webu muni.cz.
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ŠÁNA Jiří FALTEJSKOVÁ Petra SVOBODA Marek SLABÝ Ondřej

Rok publikování 2012
Druh Článek v odborném periodiku
Časopis / Zdroj Journal of Translational Medicine
Fakulta / Pracoviště MU

Středoevropský technologický institut

Citace
www http://www.translational-medicine.com/content/pdf/1479-5876-10-103.pdf
Doi http://dx.doi.org/10.1186/1479-5876-10-103
Obor Onkologie a hematologie
Klíčová slova non-coding RNAs; microRNAs; siRNAs; piRNAs; lncRNAs; cancer
Popis For the many years, the central dogma of molecular biology has been that RNA functions mainly as an informational intermediate between a DNA sequence and its encoded protein. But one of the great surprises of modern biology was the discovery that protein-coding genes represent less than 2% of the total genome sequence, and subsequently the fact that at least 90% of the human genome is actively transcribed.Thus, the human transcriptome was found to be more complex than a collection of protein-coding genes and their splice variants. Although initially argued to be spurious transcriptional noise or accumulated evolutionary debris arising from the early assembly of genes and/or the insertion of mobile genetic elements, recent evidence suggests that the non-coding RNAs (ncRNAs) may play major biological roles in cellular development, physiology and pathologies, including cancer.
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