Supramolecular complexes formation. Possibilities of mass spectrometric studies
| Autoři | |
|---|---|
| Rok publikování | 2012 |
| Druh | Další prezentace na konferencích |
| Fakulta / Pracoviště MU | |
| Citace | |
| Popis | In supramolecular complexes the molecules or ions are held together by non-covalent interactions: Host + Guest <=> {Host, Guest}. Usually, compounds like cyclic ethers, cyclodextrines, or other macrocycles might act as hosts while various organic/inorganic cations, anions, neutral molecules etc. are playing the role of guests. The paper deals with the application of mass spectrometry (MS) for fast screening of variour host-guests combinations in order to find out the formation of supramolecular complexes and/or to search for new potential drug carriers or to decrease their toxicity. MS was done using either matrices, laser desorption ionization (LDI) or surface assisted LDI. Mass spectrometric analysis was used because the reactions can also be done directly on the MS target and several combinations can be examined with the minimum amount of often scarce and expensive reagents. Several examples of supramolecular complex formation using different types of macrocycles (cyclodextrins, cucurbit[n]urils, etc.) as hosts, and either drugs like antivirals, cancerostatics or inorganics including nanoparticles as guests, will be given and discussed. The proposed application of mass spectrometry represents fast, efficient and economic way to search for the formation of new supramolecular complexes. The results might find application in medicine. |
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