Bilateral changes of IL-10 protein in lumbar and cervical dorsal root ganglia following proximal and distal chronic constriction injury of peripheral nerve
| Autoři | |
|---|---|
| Rok publikování | 2011 |
| Druh | Článek v odborném periodiku |
| Časopis / Zdroj | Neuroscience Letters |
| Fakulta / Pracoviště MU | |
| Citace | |
| Doi | http://dx.doi.org/10.1016/j.neulet.2011.06.052 |
| Obor | Neurologie, neurochirurgie, neurovědy |
| Klíčová slova | Nerve injury; Cytokines; Neuroinflammation; Sham operation |
| Přiložené soubory | |
| Popis | Interleukin-10 prevents transition of a physiological inflammatory reaction to a pathological state that may result in neuropathic pain. We studied bilateral changes of IL-10 in L4–L5 and C7–C8 dorsal root ganglia (DRG) after a chronic constriction injury (CCI) of spinal nerves or the sciatic nerve. Rats were left to survive for 1,3,7 or 14d, sham-operated for 3 or 14 d. IL-10 was detected by immunohistochemical staining and measured using ELISA analysis. Unilateral CCI induced a transient bilateral elevation in IL-10 not only in the homonymous lumbar but also in the heteronymous cervical DRG. Sham operations also induced bilateral elevation of IL-10 in both homonymous and heteronymous DRG. Our experiments revealed that the more proximal is a nerve injury the more rapid is the initial increase and slower the subsequent decrease of IL-10 in DRG. Changes of IL-10 in nonassociated DRG could be related to a general neuroinflammatory reaction of the nervous system to injury and thereby promote potential of the DRG neurons for regenerating their axons following a conditioning lesion. |
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