Baroreflex analysis in diabetes mellitus: linear and nonlinear approaches

Varování

Publikace nespadá pod Ekonomicko-správní fakultu, ale pod Lékařskou fakultu. Oficiální stránka publikace je na webu muni.cz.
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JAVORKA Michal LAZAROVA Zuzana TONHAJZEROVA Ingrid TURIANIKOVA Zuzana HONZÍKOVÁ Nataša FIŠER Bohumil JAVORKA Kamil BAUMERT Mathias

Rok publikování 2011
Druh Článek v odborném periodiku
Časopis / Zdroj Medical & Biological Engineering & Computing
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Doi http://dx.doi.org/10.1007/s11517-010-0707-x
Obor Ostatní lékařské obory
Klíčová slova Baroreflex sensitivity; Diabetes mellitus; Nonlinear analysis; Synchronization
Popis The aim of our study was to employ novel nonlinear synchronization approaches as a tool to detect baroreflex impairment in young patients with subclinical autonomic dysfunction in Type 1 diabetes mellitus (DM) and compare them to standard linear baroreflex sensitivity (BRS) methods. We recorded beat-to-beat pulse interval (PI) and systolic blood pressure (SBP) in 14 DM patients and 14 matched healthy controls. We computed the information domain synchronization index (IDSI), cross-multiscale entropy, joint symbolic dynamics, information-based similarity index (IBSI) in addition to time domain and spectral measures of BRS. This multi parametric analysis showed that baroreflex gain is well-preserved, but the time delay within the baroreflex loop is significantly increased in patients with DM. Further, the level of similarity between blood pressure and heart rate fluctuations was significantly reduced in DM. In conclusion, baroreflex function in young DM patients is changed. The quantification of nonlinear similarity and baroreflex delay in addition to baroreflex gain may provide an improved diagnostic tool for detection of subclinical autonomic dysfunction in DM.
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