Natural Compound Cudraflavone B Shows Promising Anti-inflammatory Properties in Vitro
| Autoři | |
|---|---|
| Rok publikování | 2011 |
| Druh | Článek v odborném periodiku |
| Časopis / Zdroj | Journal of Natural Products |
| Fakulta / Pracoviště MU | |
| Citace | |
| www | DOI: 10.1021/np100638h |
| Doi | http://dx.doi.org/10.1021/np100638h |
| Obor | Biochemie |
| Klíčová slova | Cudraflavone; Morus alba; anti-inflammatory; zinc-finger protein; nonsteroidal drug lead |
| Přiložené soubory | |
| Popis | Cudraflavone B (1) is a prenylated flavonoid found in large amounts in the roots of Morus alba, a plant used as a herbal remedy for its reputed anti-inflammatory properties. The present study shows that this compound causes a significant inhibition of inflammatory mediators in selected in vitro models. Thus, 1 was identified as a potent inhibitor of tumor necrosis factor R (TNFR) gene expression and secretion by blocking the translocation of nuclear factor kB (NF-kB) from the cytoplasm to the nucleus inmacrophages derived from a THP-1 human monocyte cell line. Compound 1 acts as a cyclooxygenase (COX-2 and COX-1) inhibitor with higher selectivity toward COX-2 than indomethacin. Pretreatment of cells by 1 shifted the peak in an regulatory gene zinc-finger protein 36 (ZFP36) expression assay. This natural product has noticeable antiinflammatory properties, suggesting that 1 potentially could be used for development as a nonsteroidal anti-inflammatory drug lead. |
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