Mono(pyridine-N-oxide) analog of DOTA ligand as suitable sensor for Ln(III) ions

• Autoři: LUBAL Přemysl; VANĚK Jakub; HERMANN Petr
• Rok publikování: 2010
• Druh: Konferenční abstrakty
• Fakulta / Pracoviště MU: Přírodovědecká fakulta
• Popis: Ln(III) complexes of DOTA ligand and its derivatives are utilized in many areas of medicine (e.g. complexes of metal radioisotopes as 90Y, 153Sm, 166Ho, 177Lu in nuclear medicine, Gd(III) complexes as MRI contrast agents, Eu(III)/Tb(III) complexes as luminescent probes). In this contribution, the thermodynamic and kinetic properties of Ln(III) complexes (Ln = Ce, Eu, Gd, Yb) of the mono(pyridine-N-oxide) DOTA derivative were studied by molecular absorption and emission spectroscopies (in UV/VIS region, luminescence, TRFS) in order to investigate possible analytical application of title ligand. The stability constants and acid-assisted dissociation of Ln(III) complexes show high thermodynamic stability and kinetic inertness. Ln(III) complexes show interesting photophysical properties due to presence of chromophor/fluorophor group which enables to make sensor suitable for determination of low concentration of Eu(III)/Tb(III) ions.

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