Ln(III) complexes of Mono(Pyridine-N-oxide) Analog of DOTA as a Potential Bimodal and Luminescence Imaging Agents
| Autoři | |
|---|---|
| Rok publikování | 2010 |
| Druh | Článek ve sborníku |
| Konference | Abstract book of XIV. Symposium on Luminescence Spectrometry |
| Fakulta / Pracoviště MU | |
| Citace | |
| Obor | Analytická chemie, separace |
| Klíčová slova | Macrocyclic ligand; Ln(III) ions; thermodynamics; kinetics; photophysics; analytical determination |
| Popis | Ln(III) complexes of H4dota and its derivatives are utilized in many areas of medicine. The molecular spectroscopy in UV/VIS region was employed to investigate chemical features of Eu(III)/Gd(III)/Tb(III) complexes of the title ligand in order to investigate their possible applications as bimodal agents. The stability constants and acid-assisted dissociation of Ln(III) complexes show high thermodynamic stability and kinetic inertness. In the study of formation (pH = 5.0-6.0, t = 25 C, I = 0.1 M KCl) was found that the reactive species is HL 2- and the rate increases with decreasing ionic radius of the metal ions and it follows a trend along the Ln(III) series. The ligand capable of complex formation due show interesting photophysical properties to presence of chromophor/fluorophor group and it enables to determine the low concentration of Eu(III)/Tb(III) ions. |
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