Zinc, Metallothionein and Prostate Tumour Cells - Is There Any Relation?

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Publikace nespadá pod Ekonomicko-správní fakultu, ale pod Lékařskou fakultu. Oficiální stránka publikace je na webu muni.cz.
Název česky Zinek, metalothionein a buňky karcinomu prostaty - jaká je spojitost?
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GUMULEC Jaromír CERNEI Natalia Vladimirovna ZÍTKA Ondřej MASAŘÍK Michal BABULA Petr ADAM Vojtěch KIZEK René

Rok publikování 2010
Druh Konferenční abstrakty
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Popis Prostate cells are unique in zinc metabolism, because they have the ability to accumulate high levels of these ions. In contrast, prostate cancer cells lack this ability. Metallothioneins (MT) are proteins rich in cysteine. They can bind metals including zinc. Recent studies indicate to elevated serum levels of MTin patients suffering from prostate cancer. Moreover, elevated serum levels of MT are highly specific for prostate cancer and can be potentially used as a new marker of this disease. This could be very desirable because of inaccuracies of current prostatic specific antigen (PSA) screening. The aims of this study is (1) to determine MT levels in patient's serum and cell lines PC-3 and 22RVL and compare to PSA levels, (2) to determine expression of zinc transporters in cell lines and find relations between MT and intracellular zinc levels, (3) to describe potential effects of MT and/or zinc on prostate cancer pathogenesis.
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