Genotype association of C(-735)T polymorphism in matrix metalloproteinase 2 gene with G(8002)A endothelin 1 gene with plaque psoriasis

Varování

Publikace nespadá pod Ekonomicko-správní fakultu, ale pod Lékařskou fakultu. Oficiální stránka publikace je na webu muni.cz.

Autoři	VAŠKŮ Vladimír VAŠKŮ Anna TSCHÖPLOVÁ Svatava IZAKOVIČOVÁ HOLLÁ Lydie SEMRÁDOVÁ Věra VÁCHA Jiří
Rok publikování	2002
Druh	Článek v odborném periodiku
Časopis / Zdroj	Dermatology
Fakulta / Pracoviště MU	Lékařská fakulta
Citace
Obor	Genetika a molekulární biologie
Klíčová slova	MMP-2; Endothelin-1; Gene polymorphism; Plaque psoriasis
Popis	Excessive angiogenesis is one of the characteristic features of psoriasis. To determine the possible genetic background of neo-angiogenesis in plaque psoriasis, frequent polymorphisms in matrix metalloproteinase 2 (MMP-2) and endothelin 1 (ET-1) genes were studied. A significant difference in genotype distribution of C(-735)T MMP-2 between psoriatic and control patients was found (pcorr=0.008). Two associated genotypes (CCGG and CTGG) of the two polymorphisms were significantly less frequent in psoriatic patients (pcorr=0.03 and pcorr=0.008, respectively). The results seem to reflect a different susceptibility of MMP-2 as well as of some associated MMP-2 and ET-1 genotypes to psoriasis.
Související projekty:	Molekulární patofyziologie multigenních chorob