Critical appraisal of the piRNA-PIWI axis in cancer and cancer stem cells

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Publikace nespadá pod Ekonomicko-správní fakultu, ale pod Lékařskou fakultu. Oficiální stránka publikace je na webu muni.cz.
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GARCIA-BORJA Elena SIEGL František MATEU Rosana SLABÝ Ondřej SEDO Aleksi BUSEK Petr ŠÁNA Jiří

Rok publikování 2024
Druh Článek v odborném periodiku
Časopis / Zdroj BIOMARKER RESEARCH
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www https://biomarkerres.biomedcentral.com/articles/10.1186/s40364-024-00563-3
Doi http://dx.doi.org/10.1186/s40364-024-00563-3
Klíčová slova PIWI-interacting RNAs; piRNAs; PIWI proteins; Cancer stem cells; Cancer
Přiložené soubory
Popis Small noncoding RNAs play an important role in various disease states, including cancer. PIWI proteins, a subfamily of Argonaute proteins, and PIWI-interacting RNAs (piRNAs) were originally described as germline-specific molecules that inhibit the deleterious activity of transposable elements. However, several studies have suggested a role for the piRNA-PIWI axis in somatic cells, including somatic stem cells. Dysregulated expression of piRNAs and PIWI proteins in human tumors implies that, analogously to their roles in undifferentiated cells under physiological conditions, these molecules may be important for cancer stem cells and thus contribute to cancer progression. We provide an overview of piRNA biogenesis and critically review the evidence for the role of piRNA-PIWI axis in cancer stem cells. In addition, we examine the potential of piRNAs and PIWI proteins to become biomarkers in cancer.
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