Telomerase RNA gene paralogs in plants - the usual pathway to unusual telomeres
| Autoři | |
|---|---|
| Rok publikování | 2023 |
| Druh | Článek v odborném periodiku |
| Časopis / Zdroj | New Phytologist |
| Fakulta / Pracoviště MU | |
| Citace | |
| www | https://nph.onlinelibrary.wiley.com/doi/10.1111/nph.19110 |
| Doi | http://dx.doi.org/10.1111/nph.19110 |
| Klíčová slova | evolution; land plants; mechanism of telomere transitions; telomerase RNA paralogs; unusual telomere DNA |
| Přiložené soubory | |
| Popis | Telomerase, telomeric DNA and associated proteins together represent a complex, finely tuned and functionally conserved mechanism that ensures genome integrity by protecting and maintaining chromosome ends. Changes in its components can threaten an organism's viability. Nevertheless, molecular innovation in telomere maintenance has occurred multiple times during eukaryote evolution, giving rise to species/taxa with unusual telomeric DNA sequences, telomerase components or telomerase-independent telomere maintenance. The central component of telomere maintenance machinery is telomerase RNA (TR) as it templates telomere DNA synthesis, its mutation can change telomere DNA and disrupt its recognition by telomere proteins, thereby leading to collapse of their end-protective and telomerase recruitment functions. |
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