Direct detection methods for monitoring of therapeutic staphylococcal bacteriophages in clinical samples
| Autoři | |
|---|---|
| Rok publikování | 2023 |
| Druh | Konferenční abstrakty |
| Fakulta / Pracoviště MU | |
| Citace | |
| Přiložené soubory | |
| Popis | The most promising alternative for effectively treating infections caused by Staphylococcus aureus is the application of therapeutic bacteriophages of the genus Kayvirus. Although the genomic properties of phages are well-studied, new findings are emerging on the pharmacokinetic profiling of phage drugs. The significant factors relevant to the therapeutic use of phages include i) optimal dosing, ii) duration of exposure to phages, iii) absence of phage genes for toxins and virulence factors, and iv) selection of phages suitable for the infectious agent1. Currently, there is a lack of methods for capturing and monitoring phages in clinical material. Our study aims to develop a technique for a sufficiently sensitive method for the detection and quantification of phage particles in different types of clinical material during phage therapy and clinical trials. |
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