Single-cell RNA-sequencing enables tracking and characterization of rare CLL cells with the potential to cause refractoriness.

• Autoři: KURUCOVÁ Terézia; RÉBLOVÁ Kamila; VALIŠOVÁ Martina; PORC Jakub Paweł; NAVRKALOVÁ Veronika; PAVLOVÁ Šárka; MALČÍKOVÁ Jitka; PLEVOVÁ Karla; TICHÝ Boris; DOUBEK Michael; KOTAŠKOVÁ Jana; POSPÍŠILOVÁ Šárka
• Rok publikování: 2023
• Druh: Konferenční abstrakty
• Fakulta / Pracoviště MU: Středoevropský technologický institut

Přiložené soubory

• Kurucova_et_al._EHA2023.pdf

• Popis: Chronic lymphocytic leukemia (CLL) is considered an incurable disease due to the limited ability of current treatment options to completely eradicate leukemic cells. The therapy selection pressure favors the preferential proliferation of rare resistant cells, leading to recurrent relapses. Early detection of these rare cells holds the potential to assist in selecting appropriate therapy. To explore the possibility to identify and characterize rare populations of CLL cells resistant to treatment and causing relapses, and trace the presence of such cells during the disease course by single-cell RNA sequencing (scRNA-seq).

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