Enzyme-Catalyzed Polymerization Process: A Novel Approach to the Preparation of Polyaniline Colloidal Dispersions with an Immunomodulatory Effect

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Publikace nespadá pod Ekonomicko-správní fakultu, ale pod Přírodovědeckou fakultu. Oficiální stránka publikace je na webu muni.cz.
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JASENSKÁ Daniela KAŠPÁRKOVÁ Věra VAŠÍČEK Ondřej MÜNSTER Lukáš MINAŘÍK Antonín KÁČEROVÁ Simona KORÁBKOVÁ Eva URBÁNKOVÁ Lucie VÍCHA Jan CAPÁKOVÁ Zdenka FALLETA Ermelinda CRISTINA Della Pina LEHOCKÝ Marián SKOPALOVÁ Kateřina HUMPOLÍČEK Petr

Rok publikování 2022
Druh Článek v odborném periodiku
Časopis / Zdroj Biomacromolecules
Fakulta / Pracoviště MU

Přírodovědecká fakulta

Citace
www https://pubs.acs.org/doi/10.1021/acs.biomac.2c00371
Doi http://dx.doi.org/10.1021/acs.biomac.2c00371
Klíčová slova Colloidal particles; Colloids; Plastics; Polymers; Toxicity
Popis A green, nature-friendly synthesis of polyaniline colloidal particles based on enzyme-assisted oxidation of aniline with horseradish peroxidase and chitosan or poly(vinyl alcohol) as steric stabilizers was successfully employed. Physicochemical characterization revealed formation of particles containing the polyaniline emeraldine salt and demonstrated only a minor effect of polymer stabilizers on particle morphology. All tested colloidal particles showed in vitro antioxidation activity determined via scavenging of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals. In vitro, they were able to reduce oxidative stress and inhibit the production of reactive oxygen species by neutrophils and inflammatory cytokines by macrophages. The anti-inflammatory effect observed was related to their antioxidant activity, especially in the case of neutrophils. The particles can thus be especially advantageous as active components of biomaterials modulating the early stages of inflammation. In addition to the immunomodulatory effect, the presence of intrinsically conducting polyaniline can impart cell-instructive properties to the particles. The approach to particle synthesis that we employed¦an original one using environmentally friendly and biocompatible horseradish peroxidase¦represents a smart way of preparing conducting particles with unique properties, which can be further modified by the stabilizers used.
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