DESIGN AND SYNTHESIS OF N-HYDROXY-CINNAMAMIDE DERIVATES AS NOVEL HDAC INHIBITORS: EVALUATION OF BIOLOGICAL ACTIVITY IN CANCER CELLS

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Publikace nespadá pod Ekonomicko-správní fakultu, ale pod Farmaceutickou fakultu. Oficiální stránka publikace je na webu muni.cz.
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ONUŠČÁKOVÁ Magdaléna PÍŽOVÁ Hana KAUEROVÁ Tereza HAMŠÍKOVÁ Marie BEDNÁŘ David KOLLÁR Peter BOBÁĽ Pavel

Rok publikování 2022
Druh Článek ve sborníku
Konference Czech Chemical Society Symposium Series
Fakulta / Pracoviště MU

Farmaceutická fakulta

Citace
www http://www.ccsss.cz/index.php/ccsss/issue/view/31/45
Klíčová slova HDAC inhibitors_N-Hydroxy-cinnamide_derivates cancer
Popis Histone deacetylases (HDACs) are enzymes involved in regulating fundamental cellular processes, such as cell cycle progression, differentiation, and tumorigenesis. The abnormal function of HDACs can induce various severe human diseases, including cancer, pulmonary disease, and neurodegenerative disorders. HDAC inhibitors (HDACi), which form a complex with the Zn2+ ion in the catalytic pocket of enzymes, have considerable anticancer activity. The docking study was performed using AutoDock Vina 1.2.0. program. The predicted binding affinity for HDAC enzymes suggests the high potential of the compounds tested. Biological tests confirmed the results of molecular docking.
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