Pre-implant Heart Activity Differs in Responders and Non-responders to Vagal Nerve Stimulation Therapy in Epileptic Patients

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Publikace nespadá pod Ekonomicko-správní fakultu, ale pod Lékařskou fakultu. Oficiální stránka publikace je na webu muni.cz.
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PLESINGER F. HALAMEK J. CHLÁDEK Jan JURAK P. IVORA A. DOLEŽALOVÁ Irena KORIŤÁKOVÁ Eva JURKOVÁ Tereza CHRASTINA Jan BRÁZDIL Milan

Rok publikování 2021
Druh Článek ve sborníku
Konference 43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www https://ieeexplore.ieee.org/document/9629577
Doi http://dx.doi.org/10.1109/EMBC46164.2021.9629577
Klíčová slova Pre-implant Heart Activity; Vagal Nerve Stimulation Therapy; Epileptic Patients
Popis Vagal Nerve Stimulation (VNS) is used to treat patients with pharmacoresistant epilepsy. However, generally accepted tools to predict VNS response do not exist. Here we examined two heart activity measures – mean RR and pNN50 and their complex behavior during activation in pre-implant measurements. The ECG recordings of 73 patients (38 responders, 36 non-responders) were examined in a 30-sec floating window before (120 sec), during (2x120 sec), and after (120 sec) the hyperventilation by nose and mouth. The VNS response differentiation by pNN50 was significant (min p=0.01) in the hyperventilation by a nose with a noticeable descendant trend in nominal values. The mean RR was significant (p=0.01) in the rest after the hyperventilation by mouth but after an approximately 40-sec delay.Clinical Relevance— Our study shows that pNN50 and mean RR can be used to distinguish between VNS responders and non-responders. However, details of dynamic behavior showed how this ability varies in tested measurement segments.
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