In vivo Molecular Signatures of Cervical Spinal Cord Pathology in Degenerative Compression

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Publikace nespadá pod Ekonomicko-správní fakultu, ale pod Lékařskou fakultu. Oficiální stránka publikace je na webu muni.cz.
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HORÁK Tomáš HORÁKOVÁ Magda SVÁTKOVÁ Alena KADAŇKA Zdeněk KUDLIČKA Petr VALOSEK Jan ROHAN Tomáš KEŘKOVSKÝ Miloš VLČKOVÁ Eva KADAŇKA Zdeněk DEELCHAND Dinesh K. HENRY Pierre-Gilles BEDNAŘÍK Josef BEDNAŘÍK Petr

Rok publikování 2021
Druh Článek v odborném periodiku
Časopis / Zdroj Journal of Neurotrauma
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www https://www.liebertpub.com/doi/10.1089/neu.2021.0151
Doi http://dx.doi.org/10.1089/neu.2021.0151
Klíčová slova cervical spinal cord; compression; degenerative magnetic resonance; myelopathy; spectroscopy
Popis Degenerative cervical myelopathy (DCM) is a severe consequence of degenerative cervical spinal cord (CSC) compression. The non-myelopathic stage of compression (NMDC) is highly prevalent and often progresses to disabling DCM. This study aims to disclose markers of progressive neurochemical alterations in NMDC and DCM by utilizing an approach based on state-of-the-art proton magnetic resonance spectroscopy (1H-MRS). Proton-MRS data were prospectively acquired from 73 participants with CSC compression and 47 healthy controls (HCs). The MRS voxel was centered at the C2 level. Compression-affected participants were clinically categorized as NMDC and DCM, radiologically as mild (MC) or severe (SC) compression. CSC volumes and neurochemical concentrations were compared between cohorts (HC vs. NMDC vs. DCM and HC vs. MC vs. SC) with general linear models adjusted for age and height (pFWE < 0.05) and correlated to stenosis severity, electrophysiology, and myelopathy symptoms (p?<?0.05). Whereas the ratio of total creatine (tCr) to total N-acetylaspartate (tNAA) increased in NMDC (+11%) and in DCM (+26%) and SC (+21%), myo-inositol/tNAA, glutamate + glutamine/tNAA, and volumes changed only in DCM (+20%, +73%, and -14%) and SC (+12%, +46%, and -8%, respectively) relative to HCs. Both tCr/tNAA and myo-inositol/tNAA correlated with compression severity and volume (-0.376 < r < -0.259). Myo-inositol/tNAA correlated with myelopathy symptoms (r?=?-0.670), whereas CSC volume did not. Short-echo 1H-MRS provided neurochemical signatures of CSC impairment that reflected compression severity and clinical significance. Whereas volumetry only reflected clinically manifest myelopathy (DCM), MRS detected neurochemical changes already before the onset of myelopathy symptoms.
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