Childhood survivors of high-risk neuroblastoma show signs of immune recovery and not immunosenescence
Autoři | |
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Rok publikování | 2020 |
Druh | Článek v odborném periodiku |
Časopis / Zdroj | EUROPEAN JOURNAL OF IMMUNOLOGY |
Fakulta / Pracoviště MU | |
Citace | |
www | https://onlinelibrary.wiley.com/doi/full/10.1002/eji.202048541 |
Doi | http://dx.doi.org/10.1002/eji.202048541 |
Klíčová slova | adverse late effects; childhood; immune recovery; immunosenescence; neuroblastoma |
Popis | Neuroblastoma survivors show signs of immunosenescence early after therapy in CD8(+)T cell compartment and elevated plasma TNF-alpha but in later follow-up immune recovery comes into play. Whether the recovery phenotype is long lasting or transient remains to be elucidated, however, late adverse effects often occur in childhood cancer survivors. |
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