RAPID EARLY PROGRESSION OF GLIOBLASTOMA IS NOT RELATED TO CORTICAL/NEURAL STEM CELLS REGIONS

• Autoři: JANČÁLEK Radim; KAZDA Tomáš; BELANOVÁ Renata; POSPÍŠIL Petr; BURKOŇ Petr; HYNKOVÁ Ludmila; ŠLAMPA Pavel; LAKOMÝ Radek
• Rok publikování: 2019
• Druh: Konferenční abstrakty
• Fakulta / Pracoviště MU: Lékařská fakulta
• Popis: Rapid early progression (REP) of glioblastoma after surgery is quite often observed on pre-radiotherapy MR scan. Clinical and molecular biomarkers indicating increased risk of this REP may be of high clinical need. Subventricular brain zone (SVZ) and hippocampal regions are supposed to harbor astrocyte-like neural stem cells with tumors arising from these transformed SVZ stem cells dreaded to be of higher risk of REP. Lim's et al classification of initial glioblastoma location related to these neural stem cells regions was predictive for invasive and multifocal tumor phenotype. The aim of this retrospective single-institutional study is to evaluate the relations of this Lim classification on REP in unselected cohort of glioblastoma patients.

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