Anterior thalamic deep brain stimulation in epilepsy and persistent psychiatric side effects following discontinuation

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Publikace nespadá pod Ekonomicko-správní fakultu, ale pod Lékařskou fakultu. Oficiální stránka publikace je na webu muni.cz.
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DOLEŽALOVÁ Irena KUNST Jonáš KOJAN Martin CHRASTINA Jan BALÁŽ Marek BRÁZDIL Milan

Rok publikování 2019
Druh Článek v odborném periodiku
Časopis / Zdroj Epilepsy and Behavior Reports
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www https://www.sciencedirect.com/science/article/pii/S2589986419301297?via%3Dihub
Doi http://dx.doi.org/10.1016/j.ebr.2019.100344
Klíčová slova Case report; Deep brain stimulation of the anterior nucleus of the thalamus
Popis We report a case of a patient with drug-resistant epilepsy treated with deep brain stimulation of the anterior nucleus of the thalamus (ANT-DBS). The patient developed psychiatric side effects (PSEs), namely irritability, hostility, aggressiveness, and paranoia, after implantation and stimulation initiation. The stimulation was discontinued and the PSEs were mitigated, but the patient did not return to her pre-implantation state, as documented by repeated psychiatric reports and hospitalizations. To our knowledge, this is the first report of a patient who developed long-term PSEs that did not disappear after stimulation discontinuation. We suppose that ANT-DBS caused a persistent perturbation of the thalamic neuronal networks that are responsible for long-term PSEs.
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