The role of MYC in the transformation and aggressiveness of ?indolent? B-cell malignancies

Varování

Publikace nespadá pod Ekonomicko-správní fakultu, ale pod Středoevropský technologický institut. Oficiální stránka publikace je na webu muni.cz.
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FILIP Daniel MRÁZ Marek

Rok publikování 2020
Druh Článek v odborném periodiku
Časopis / Zdroj LEUKEMIA & LYMPHOMA
Fakulta / Pracoviště MU

Středoevropský technologický institut

Citace
www https://www.tandfonline.com/doi/full/10.1080/10428194.2019.1675877
Doi http://dx.doi.org/10.1080/10428194.2019.1675877
Klíčová slova Lymphomas; indolent mature B-cell malignancies; transformation; MYC; microRNA
Popis MYC was found to be involved in many germinal center derived lymphomas, and more recently in the histological transformation of indolent mature B-cell malignancies, such as follicular lymphoma (FL), chronic lymphocytic leukemia (CLL) and mucosa-associated lymphoid tissue lymphoma (MALT) to aggressive diffuse large B-cell lymphoma (DLBCL). Pathological MYC activity gain in lymphomas is able to overcome its regulation by repressors, which leads to bypassing the affinity-based selection of B-cells. Arguably the MYC activity gain is the most constantly observed phenomenon (>70% of cases) in transformed FL/MALT/CLL (Richter?s transformation) and co-occurs with specific aberrations such as the loss of p53, CDKN2A/B, or gain of BCL2/BCL6. Here we summarize recent progress in the understanding of MYC regulatory network in lymphoma B-cells and highlight its involvement in lymphomas? histological transformation by regulating cyclins, CDKs, p21, p27, BCL2, E2F, FOXP1, BCR signaling components, and non-coding microRNA (miRNA) genes such as miR-150, miR-29, miR-17-92, and miR-34a.
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