Trends in incidence of childhood cancers in the Czech Republic: population-based analysis of national registries (1994-2014)

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Publikace nespadá pod Ekonomicko-správní fakultu, ale pod Lékařskou fakultu. Oficiální stránka publikace je na webu muni.cz.
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KODYTKOVÁ Daniela BAJČIOVÁ Viera KREJČÍ Denisa ZAPLETALOVÁ M. DUSEK V. JARKOVSKÝ Jiří MUŽÍK Jan KLIMEŠ Daniel STARY J. SMELHAUS V. VRZALOVA A. JANOTOVA I. ŠTĚRBA Jaroslav DUŠEK Ladislav

Rok publikování 2018
Druh Článek v odborném periodiku
Časopis / Zdroj Neoplasma
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www http://dx.doi.org/10.4149/neo_2018_170517N358
Doi http://dx.doi.org/10.4149/neo_2018_170517N358
Klíčová slova childhood; cancer; registry; incidence; epidemiology; Czech Republic
Popis The purpose of this study is to summarize incidence and trends in the pediatric cancer burden in the Czech Republic over the period 1994-2014. The recently established Childhood Cancer Registry was combined with retrospective data from the Czech National Cancer Registry to analyze the annual patterns of incidence and long-term trends of pediatric cancer patients aged 0-14 years diagnosed between 1994 and 2014. Malignancies were classified according to the International Classification of Childhood Cancer. The distribution of incidence was stratified according to gender, age at diagnosis, type of cancer and geographic area. Annual age-standardized rates were adjusted using the world standard population. Changes over time were quantified as the average annual percentage change. This analysis comprised records of 5,605 children diagnosed with cancer within the period 1994-2014, annually 267 records on average; the overall age-standardized average annual incidence rate was 169 cases per million. Boys were affected more frequently than girls: the M/F crude incidence ratio was 1.2:1. The highest incidence rates were observed for ICCC groups I (27.8%), III (21.8%), II(12.4%) and IV (7.8%); other groups formed 30.2%. There are significant differences in the geographic distribution of incidence between regions. A borderline statistically significant increase (0.6%) in the overall average annual percentage change was detected between 1994 and 2014 (95% CI: 0.01 to 1.12; p = 0.05). This study provides reliable recent information on trends in the incidence of childhood cancers in the Czech Republic.
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