A modified mathematical model of human ventricular cardiomyocyte incorporating separate t-tubular and surface dyads and submembrane spaces

Varování

Publikace nespadá pod Ekonomicko-správní fakultu, ale pod Lékařskou fakultu. Oficiální stránka publikace je na webu muni.cz.
Autoři

PÁSEK Michal BÉBAROVÁ Markéta CHRISTÉ Georges

Rok publikování 2017
Druh Článek ve sborníku
Konference Engineering Mechanics 2017
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www http://www.engmech.cz/2017/im/doc/EM2017_proceedings_all.pdf
Obor Fyziologie
Klíčová slova Human ventricular cell model; T-tubules; Dyads; Subsarcolemmal spaces; Calcium cycling
Popis Intracellular Ca2+ load and Ca2+ transient are considerably dependent on distribution of sarcolemmal Ca2+ pump and Na+-Ca2+ exchanger between the t-tubular and surface membranes in the presence of separate dyadic and subsarcolemmal spaces in rat ventricular cell model. To explore analogical phenomenon in human, we modified our previously published model of human ventricular myocyte. When the t-tubular fractions of Na+-Ca2+ exchanger and of sarcolemmal Ca2+ pump were increased to the newly proposed value of 0.95 in the modified model, the following changes were observed at 1 Hz steady-state stimulation: a shortening of the action potential duration at 90 % repolarisation by 6 % and an increase of the cytosolic Ca2+ transient by 22 %. Further analysis revealed a critical role of Ca2+ concentration changes in the subsarcolemmal spaces and consequent change in cellular Ca2+ cycling in this effect.
Související projekty:

Používáte starou verzi internetového prohlížeče. Doporučujeme aktualizovat Váš prohlížeč na nejnovější verzi.