Deregulated expression of long non-coding RNA UCA1 in multiple myeloma

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Publikace nespadá pod Ekonomicko-správní fakultu, ale pod Lékařskou fakultu. Oficiální stránka publikace je na webu muni.cz.
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SEDLAŘÍKOVÁ Lenka GROMESOVÁ Barbora KUBACZKOVÁ Veronika RADOVÁ Lenka FILIPOVA Jana JARKOVSKÝ Jiří BROŽOVÁ Lucie VELICHOVÁ Roberta ALMÁŠI Martina PENKA Miroslav BEZDĚKOVÁ Renata ŠTORK Martin ADAM Zdeněk POUR Luděk KREJČÍ Marta KUGLÍK Petr HÁJEK Roman ŠEVČÍKOVÁ Sabina

Rok publikování 2017
Druh Článek v odborném periodiku
Časopis / Zdroj European Journal of Haematology
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Doi http://dx.doi.org/10.1111/ejh.12908
Obor Onkologie a hematologie
Klíčová slova biomarker; long non-coding RNA; multiple myeloma; plasma cells; prognosis; quantitative real-time PCR
Popis ObjectivesLong non-coding RNAs (lncRNAs) are RNA transcripts longer than 200 nucleotides that are not translated into proteins. They are involved in pathogenesis of many diseases including cancer and have a potential to serve as diagnostic and prognostic markers. We aimed to investigate lncRNA expression profiles in bone marrow plasma cells (BMPCs) of newly diagnosed multiple myeloma (MM) patients in comparison to normal BMPCs of healthy donors (HD) in a three-phase biomarker study. MethodsExpression profile of 83 lncRNA was performed by RT2 lncRNA PCR Array (Qiagen), followed by quantitative real-time PCR using specific TaqMan non-coding RNA assays analyzing 84 newly diagnosed MM patients and 25 HD. ResultsOur analysis revealed dysregulation of two lncRNAs; NEAT1 (sensitivity of 55.0% and specificity of 79.0%) and UCA1 (sensitivity of 85.0% and specificity of 94.7%). UCA1 levels correlated with albumin and monoclonal immunoglobulin serum levels, cytogenetic aberrations, and survival of MM patients. ConclusionOur study suggests a possible prognostic impact of UCA1 expression levels on MM patients.
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