Broadening the spectrum of controls for skin biopsy in painful neuropathies: spondylotic cervical myelopathy patients with painful feet

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Publikace nespadá pod Ekonomicko-správní fakultu, ale pod Lékařskou fakultu. Oficiální stránka publikace je na webu muni.cz.
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KOVAĽOVÁ Ivana VLČKOVÁ Eva BEDNAŘÍK Josef

Rok publikování 2016
Druh Článek v odborném periodiku
Časopis / Zdroj Brain and Behavior
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Doi http://dx.doi.org/10.1002/brb3.444
Obor Neurologie, neurochirurgie, neurovědy
Klíčová slova cervical spondylotic myelopathy; epidermal nerve fibers; neuropathic pain; peripheral neuropathy; skin biopsy
Přiložené soubory
Popis Purpose: Intraepidermal nerve fiber density (IENFD) is useful in the evaluation of small-fiber neuropathy (SFN). Recent guidelines recommend extending the spectrum of controls for IENFD assessment by evaluation of patients whose clinical picture mimics that of SFN. The aim of this study was to broaden the spectrum of IENFD controls by the assessment of patients with cervical spondylotic myelopathy (CSM) and painful feet. Methods: Evaluation of IENFD from skin biopsy samples and quantitative sensory testing (QST) were performed in a cohort of 14 CSM patients (eight men, median age: 58; range: 46–63 years), with painful feet, exhibiting no clinical or electrophysiological signs of largefiber polyneuropathy, and no risk factors for peripheral neuropathies. Results: Quantitative sensory testing abnormalities were found in all but two of the CSM patients (86%), while the IENFD values were within reference range. The mean IENFD value (6.87 2.78 fibers/mm) did not differ from that of an ageand sex-matched cohort of healthy volunteers (7.97 2.21 fibers/mm, P > 0.05). Conclusions: The study confirmed normal skin biopsy findings in patients with CSM as one of the clinical conditions mimicking SFN and provided further support for the use of IENFD assessment in case of suspicion of SFN.
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