CD36 and GPR120 differently mediate Ca2+ signaling in human taste bud cells

Varování

Publikace nespadá pod Ekonomicko-správní fakultu, ale pod Přírodovědeckou fakultu. Oficiální stránka publikace je na webu muni.cz.

Autoři	SUBRAMANIAM Selvakumar OZDENER Mehmet Hakan SUNDARESAN Sinju ŠERÝ Omar BESNARD Philippe ABUMRAD Nada A KHAN Naim Akhtar
Rok publikování	2014
Druh	Článek ve sborníku
Konference	FUNDAMENTAL & CLINICAL PHARMACOLOGY
Fakulta / Pracoviště MU	Přírodovědecká fakulta
Citace
Doi	http://dx.doi.org/10.1111/fcp.12064
Obor	Fyziologie
Klíčová slova	oral; fat; lipid; taste; bud
Popis	High concentrations of linoleic acid induced Ca(2+) signaling via CD36 and GPR120 in human and mice TBC, as well as in STC-1 cells, and low concentrations induced Ca(2+) signaling via only CD36. Incubation of human and mice fungiform TBC with lineoleic acid down-regulated CD36 and up-regulated GPR120 in membrane lipid rafts. Obese mice had decreased spontaneous preference for fat. Fungiform TBC from obese mice had reduced Ca(2+) and serotonin responses, but increased release of glucagon-like peptide-1, along with reduced levels of CD36 and increased levels of GPR120 in lipid rafts. CONCLUSIONS: CD36 and GPR120 have nonoverlapping roles in TBC signaling during orogustatory perception of dietary lipids; these are differentially regulated by obesity.
Související projekty:	Podpora biochemického výzkumu v roce 2016