Linking in Vitro Effects and Detected Organic Micropollutants in Surface Water Using Mixture-Toxicity Modeling

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Publikace nespadá pod Ekonomicko-správní fakultu, ale pod Přírodovědeckou fakultu. Oficiální stránka publikace je na webu muni.cz.
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NEALE Peta A. AIT-AISSA Selim BRACK Werner CREUSOT Nicolas DENISON Michael S. DEUTSCHMANN Bjoern HILSCHEROVÁ Klára HOLLERT Henner KRAUSS Martin NOVÁK Jiří SCHULZE Tobias SEILER Thomas-Benjamin SERRA Helene SHAO Ying ESCHER Beate I.

Rok publikování 2015
Druh Článek v odborném periodiku
Časopis / Zdroj ENVIRONMENTAL SCIENCE & TECHNOLOGY
Fakulta / Pracoviště MU

Přírodovědecká fakulta

Citace
www http://pubs.acs.org/doi/10.1021/acs.est.5b04083
Doi http://dx.doi.org/10.1021/acs.est.5b04083
Obor Znečištění a kontrola vody
Klíčová slova ARYL-HYDROCARBON RECEPTOR; OXIDATIVE STRESS-RESPONSE; TREATMENT-PLANT EFFLUENTS; QUALITY TRIGGER VALUES; PREGNANE X RECEPTOR; WASTE-WATER; CHEMICAL-ANALYSIS; RISK-ASSESSMENT; CONCEPTUAL-FRAMEWORK; THYROID-HORMONE
Popis Surface water can contain countless organic micropollutants, and targeted chemical analysis alone may only detect a small fraction of the chemicals present. Consequently, bioanalytical tools can be applied complementary to chemical analysis to detect the effects of complex chemical mixtures. In this study, bioassays indicative of activation of the aryl hydrocarbon receptor (AhR), activation of the pregnane X receptor (PXR), activation of the estrogen receptor (ER), adaptive stress responses to oxidative stress (Nrf2), genotoxicity (p53) and inflammation (NF-kappa B) and the fish embryo toxicity test were applied along with chemical analysis to water extracts from the Danube River. Mixture-toxicity modeling was applied to determine the contribution of detected chemicals to the biological effect. Effect concentrations for between 0 to 13 detected chemicals could be found in the literature for the different bioassays. Detected chemicals explained less than 0.2% of the biological effect in the PXR activation, adaptive stress response, and fish embryo toxicity assays, while five chemicals explained up to 80% of ER activation, and three chemicals explained up to 71% of AhR activation. This study highlights the importance of fingerprinting the effects of detected chemicals.
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