Biophysical and electrochemical studies of protein-nucleic acid interactions

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Publikace nespadá pod Ekonomicko-správní fakultu, ale pod Středoevropský technologický institut. Oficiální stránka publikace je na webu muni.cz.
Autoři

BOWATER Richard P. COBB Andrew M. PIVOŇKOVÁ Hana HAVRAN Luděk FOJTA Miroslav

Rok publikování 2015
Druh Článek v odborném periodiku
Časopis / Zdroj Monatshefte fur Chemie
Fakulta / Pracoviště MU

Středoevropský technologický institut

Citace
www http://download.springer.com/static/pdf/555/art%253A10.1007%252Fs00706-014-1405-4.pdf?originUrl=http%3A%2F%2Flink.springer.com%2Farticle%2F10.1007%2Fs00706-014-1405-4&token2=exp=1451981438~acl=%2Fstatic%2Fpdf%2F555%2Fart%25253A10.1007%25252Fs00706-014-14
Doi http://dx.doi.org/10.1007/s00706-014-1405-4
Obor Biofyzika
Klíčová slova Bioorganic chemistry; Biosensors; Electrochemistry; Electron transfer; Electrophoresis; Nucleic acids; Proteins; Voltammetry
Popis This review is devoted to biophysical and electrochemical methods used for studying protein-nucleic acid (NA) interactions. The importance of NA structure and protein-NA recognition for essential cellular processes, such as replication or transcription, is discussed to provide background for description of a range of biophysical chemistry methods that are applied to study a wide scope of protein-DNA and protein-RNA complexes. These techniques employ different detection principles with specific advantages and limitations and are often combined as mutually complementary approaches to provide a complete description of the interactions. Electrochemical methods have proven to be of great utility in such studies because they provide sensitive measurements and can be combined with other approaches that facilitate the protein-NA interactions. Recent applications of electrochemical methods in studies of protein-NA interactions are discussed in detail. [GRAPHICS] .
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