Interleukin-6 May Contribute to Mortality in Parkinson's Disease Patients: A 4-Year Prospective Study

Logo poskytovatele

Varování

Publikace nespadá pod Ekonomicko-správní fakultu, ale pod Lékařskou fakultu. Oficiální stránka publikace je na webu muni.cz.
Autoři

DUFEK Michal REKTOROVÁ Irena THON Vojtěch LOKAJ Jindřich REKTOR Ivan

Rok publikování 2015
Druh Článek v odborném periodiku
Časopis / Zdroj Parkinsons Disease
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www http://www.hindawi.com/journals/pd/2015/898192/
Doi http://dx.doi.org/10.1155/2015/898192
Obor Neurologie, neurochirurgie, neurovědy
Klíčová slova GROWTH-FACTOR-ALPHA; C-REACTIVE PROTEIN; CEREBROSPINAL-FLUID; CYTOKINE PRODUCTION; ATHEROSCLEROSIS; INFLAMMATION; RISK; HEALTH; BRAIN; IL-6
Přiložené soubory
Popis Objectives. The association between abnormal serum immunomarkers and mortality in 53 consecutive Parkinson's disease patients was studied. Materials and Methods. The plasma level of specific inflammatory cytokines was investigated: mannan-binding lectin (MBL), interleukin-(IL-) 6, and tumor necrosis factor-alpha (TNF-alpha). The baseline serum immunomarkers obtained from patients who died (n = 16) during a four-year follow-up period were compared with the data of patients who survived (n = 37). Results. The baseline level of IL-6 was significantly higher in the deceased patients than in the survivors. Elevated IL-6 levels and age were major independent contributors to disease mortality. Differences between other plasma cytokine level abnormalities were not significant. Conclusion. This study showed that IL-6 elevation may be a marker of increased mortality risk in Parkinson's disease patients. The inflammation may act in association with other factors and comorbidities in progressive neurodegenerative pathology.
Související projekty:

Používáte starou verzi internetového prohlížeče. Doporučujeme aktualizovat Váš prohlížeč na nejnovější verzi.