CHAP domain of tail-associated protein from phage 812 and its lytic activity against Staphylococcus aureus

• Autoři: BENEŠÍK Martin; DOPITOVÁ Radka; JANDA Lubomír; DOŠKAŘ Jiří; MOŠA Marek; BOŠTÍK Josef; PANTŮČEK Roman
• Rok publikování: 2014
• Druh: Článek v odborném periodiku
• Časopis / Zdroj: Russian Journal of Infection and Immunity
• Fakulta / Pracoviště MU: Přírodovědecká fakulta
• www: http://iimmun.ru/index.php/iimm
• Obor: Genetika a molekulární biologie
• Popis: The increasing number of pathogenic bacteria resistant to antimicrobial agents is a serious public health problem. Phage therapy appears to be a suitable alternative to antibiotics treatment. In history, it was envisaged to use bacteriophages as antimicrobial agents but recently, the research focus on phage encoded antimicrobial proteins. Bacteriophages produce lytic enzymes two times during their lytic cycle. In this study we focused on tail hydrolase of polyvalent staphylococcal bacteriophage 812, a member of SPO1-like viruses from family Myoviridae. This enzyme play role in the beginning of phage lytic cycle. It disturbs bacteria cell wall for injection of phage DNA into bacterial cell. This lytic enzyme can be possible use as antimicrobial agents against S. aureus bacterial cells.

Související projekty

• Výzkum stafylokokových bakteriofágových mutant s širokým spektrem hostitelů