Splenic marginal-zone lymphoma: ontogeny and genetics

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Publikace nespadá pod Ekonomicko-správní fakultu, ale pod Středoevropský technologický institut. Oficiální stránka publikace je na webu muni.cz.
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BALIAKAS Panagiotis STREFFORD Jonathan C. BIKOS Vasileios PARRY Marina STAMATOPOULOS Kostas OSCIER David

Rok publikování 2015
Druh Článek v odborném periodiku
Časopis / Zdroj Leukemia & Lymphoma
Fakulta / Pracoviště MU

Středoevropský technologický institut

Citace
www http://informahealthcare.com/doi/abs/10.3109/10428194.2014.919636
Doi http://dx.doi.org/10.3109/10428194.2014.919636
Obor Onkologie a hematologie
Klíčová slova Lymphoma and Hodgkin disease; cytogenetics; molecular genetics
Přiložené soubory
Popis Splenic marginal-zone lymphoma (SMZL) is a rare tumor that has recently emerged as a prototype for how the interplay between genetics and environment shapes the natural history of lymphomas. Indeed, the recent identification of molecular immunogenetic subgroups within SMZL may prove to be relevant not only for the sub-classification of the disease but also for improved understanding of the underlying biology. In contrast to other B-cell lymphomas, SMZL lacks a characteristic genetic lesion, although the majority of cases harbor genomic aberrations, as recently revealed by high-throughput studies that identified recurrent genetic aberrations, several in pathways related to marginal-zone differentiation and B-cell signaling. Here we provide an overview of recent research into the molecular and cellular biology of SMZL and related disorders, with special emphasis on immunogenetics and genomic aberrations, and discuss the value of molecular and cellular markers for the diagnosis and differential diagnosis of these entities.
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