MiR-205 as a tumor suppressor in adenocarcinoma and oncogene in spinocellular carcinoma of esophageal cancer.

• Autoři: HÉŽOVÁ Renata; KOVAŘÍKOVÁ Alena; SROVNAL Josef; ZEMANOVÁ Milada; HARUŠTIAK Tomáš; EHRMANN Jiří; HAJDÚCH Marian; FABIAN Pavel; ŠACHLOVÁ Milana; SLABÝ Ondřej
• Rok publikování: 2014
• Druh: Konferenční abstrakty
• Fakulta / Pracoviště MU: Středoevropský technologický institut
• Popis: Esophageal cancer is disease with very poor prognosis. There are two main types of esophageal carcinoma: adenocarcinoma (EAC) and esophageal squamous cell carcinoma (ESCC). The aim of this study is to identify potential microRNA (miRNA) as biomarkers of esophageal cancer.Our results indicate a significantly decreased expression of miR-205 in EAC patients (n=22) in comparison with adjacent mucosa and significantly decreased expression of miR-205 in EAC patients in comparison with ESSC (n=22).Increased level of miR-205 is associated with a significantly better overall survival of EAC patients. Experimentally decreased level of anti-miR-205 in ESCC cell line was significantly affecting cell proliferation, migration and anchorage independent growth. Conversely, experimental increase of miR-205 in EAC cell line leads to decrease in cell proliferation and cell migration. This study may suggest the possibility of using miR-205 as biomarker for more reliable diagnosis of esophageal cancer and distinguishing of EAC from ESCC.

Související projekty

• Studium mikroRNA a genů asociovaných s procesem epiteliálně-mezenchymální tranzice jako potenciálních markerů pro predikci rizika a časný záchyt metastazování u pacientů s renálním karcinomem
• Vytvoření diagnostické sady cirkulujících mikroRNA pro neinvazivní časnou diagnostiku a sledování pacientů s kolorektálním karcinomem